The thought of creepy crawlies in your bed is not a nice one. Bed bugs are a nighttime evil none of us want to come face-to-face, or body-to-bug, with. For a bite-free sleep and peace of mind knowing your mattress is free from these nasty critters, you need the best bed bugs spray.
Consistent application of this bug-killing spray can help to gain control of bed bug outbreaks and prevent them as well. If you’re looking for the latter, know that there are many other types of bed bug protection available, including professional extermination, mattress protectors and other bug-killing gadgets. But, bed bug spray is most certainly the best way to protect your bed or clear an existing problem. Here are a few reasons why:
- Effective – The power of bed bug spray is felt by its victims within a matter of minutes. It’s a quick way to kill bed bugs along with other unwanted creatures, such as mites and fleas.
- Efficient – Investing in a decent, well-reviewed and proven-to-protect spray can cost under $20, which is a lot less than an exterminator visit. Alongside being cost-efficient, bed bug spray is also one of the least time-consuming treatments. So, you can save in multiple ways without compromising on quality.
- User-Friendly – Anyone with a pair of hands and a calendar can effectively use bed bug spray. For the best results, you use a spray consistently, usually two to three weeks apart. Plus, certain products come with an extendable spray gun, so you can release your inner Ghostbuster while you’re at it.
- Compact – As wonderful as hotel beds are, a lot of people have slept in them. Having a travel-sized bed bug spray on hand for a quick spruce on arrival is often a good idea.
Buying the best bed bugs spray is not the most glamorous purchase, but it is an important one. We’ve rounded up 12 of the best bed bug killers and protectors on Amazon. There are a range of products available that are suitable to different types of home along with two alternative products, if you’d prefer to avoid a spray treatment. But, for the best bug-free bed, we highly recommend the best bed bugs spray.
1. Ortho Bed Bug Spray
BEST OVERALL
Ortho suggests using their Bed Bug Spray as the second step in a bed bug protection routine, following their detection traps. A fold-out wand is attached to the large, 1-gallon reservoir for a comfortable and continuous spray. Not only does this spray strongly protect against bed bugs, it also kills their eggs, fleas and ticks upon contact. This is a great product for homes with multiple beds or anyone looking for effective bed bug treatment and prevention.

2. Hot Shot Bed Bug Insect Killer
BEST VALUE
With a very modest price tag of under seven dollars and over 2,000 reviews on Amazon, Hot Shot Bed Bug Insect Killer is a wise buy for anyone with a bed. It’s suitable for use indoors and protects against all types of bed bugs, fleas and dust mites. Using this protection as part of a cleaning cycle is the best way to enforce effective prevention of an infestation.

3. Eagle Watch Natural Bed Bug Spray
BEST SPRAY FOR TRAVEL
Eagle Watch is a brand created by a US veteran, Anthony Watson, who has experienced the depths of bed bug infestations first hand. He made it his mission to produce a bed bug spray which both prevents and kills. After years of research and testing, his natural formula is now capable of knocking down bugs in a whopping three seconds.

4. Proof Bed Bug & Dust Mite Killer
BEST PLANT-BASED SPRAY
Good prevails with Proof Bed Bug & Dust Mite Killer, as their plant-based concoction is both kind to the environment and deadly to bed bugs. For the best results, follow the recommended four-step process. You’ll simply need to shake and spray, let it sit for four hours, air out the room, if needed, and then wipe down. Once applied, this spray protects against adult bugs for two weeks and eggs for up to three weeks.

5. Eco Defense Bed Bug Spray
MOST ECO-FRIENDLY
Made of all-natural ingredients, Eco Defense Bed Bug Spray is an eco-friendly way to deter unwanted bed enemies. Distilled water, citric acid and ethyl lactate make up the mix, along with small percentages of sodium lauryl sulfate and geranium oil. Bed bugs, their eggs and their nymphs will be history with a consistent use of this bed bug spray every two weeks.

6. EcoRaider Bed Bug Killer
BEST REVIEWED
With nearly 10,000 reviews, EcoRaider Bed Bug Killer is one of the best reviewed bed bugs spray on Amazon. A combination of active and inert ingredients ensure this non-toxic spray is 100% efficient at killing bed bugs. You can use the spray both on bedding and the surrounding area thanks to the natural formula, which is ideal for sensitive environments.

7. Dr. Killigan’s Rest in Peace Bed Bug Spray
BEST NOVELTY
Although you wouldn’t usually look to a bottle of bug spray to brighten up your day, the dark humour of Dr. Killigan’s Rest in Peace Bed Bug Spray is sure to help you crack a smile. Despite its novelty, this spray means business when it comes to eradicating bed bugs from your home. Inside the gloomy exterior is a spray infused with scents of vanilla and mint for a pleasant finishing touch.

8. Raid Max Bed Bug Extended Protection
BEST EIGHT WEEK PROTECTION
Eight weeks of a bed bug free bliss is a fair expectation when using Raid Max Bed Bug Extended Protection. If the spray directly contacts the bugs, it’s capable of getting rid of the unwanted guests within minutes, after which the spray then continues to prevent any further infestation for weeks to come. The neck of the bottle features three comfort ridges for a firm grip, enabling a strong and targeted spray.

9. Premo Guard Bed Bug & Mite Spray
BEST MITE SPRAY
Give Premo Guard Bed Bug & Mite Spray a good shake before use to ensure all the ingredients are well mixed and ready for action. The stain-free formula is scent free and is designed by a team of entomologists who focus on the use of natural products. Although this bed bug spray has a higher price tag than most others, it prides itself on being a premium spray able to kill all stages bed bugs can take.

10. HARRIS Bed Bug Killer
BEST SPLURGE
To be the ultimate exterminator of bed bugs, you need to be armed with HARRIS Bed Bug Killer. This one-gallon, handled tank comes complete with a hazard yellow spray gun attached by extension pipe for further reach. With great investment comes great protection, as this spray continues to kill bed bugs for up to 16 weeks after you first apply it to the target zone. Plus, the spray is odorless and does not cause damage to upholstered furniture.

Also Consider: More Bed Bug Treatments
If you’re not convinced that the best bed bugs spray will help take care of your problem, consider these alternative options. Bed bug mattress protectors are a popular option, and we’ve also included an option that’s safe for kids and pets.
Of course, should the options on this list fail, you’lll need to call a professional exterminator to get rid of your bed bug infestation for good.
Linenspa Bed Bug Proof Mattress Protector
BEST MATTRESS PROTECTOR
For 360-degree bed bug protection, wrap your mattress in the Linenspa Bed Bug Proof Mattress Protector. All six sides are covered and tightly enclosed, thanks to the zip fastening. The lightweight polyester material from which the protector is made creates a reliable barrier between your mattress and unwanted bugs, mites or allergens. Once in place, why not further protect your bed with the use of bug spray as well?

12. ECOPEST Bed Bug Interceptors
BEST ALTERNATIVE PROTECTION
As one of the top rated bed bug deterrents on Amazon, the ECOPEST Bed Bug Interceptors are a pet and child-safe way to protect your home. Eight units are included within each order, which is enough for two standard beds. They work by creating a too-deep-to-climb moat which the bugs fall into enroute to your bed. This makes it so the pests never get too close for comfort. When it’s time to rise and shine, you can empty the traps and see just how effective these anti-bug tools are.

This Mini Vacuum Cleaner Kills Dust Mites, Allergens and Even Bed Bugs and It’s Only $69 Right Now